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Faculty Profile Last Modified Time: 10:50:43 AM Wed, 19 Apr 2023   Contact Information Robia Pautler Associated Profiles  Professor, Molecular Physiology, Baylor College of Medicine   Mail Box: BCM335    rpautler@bcm.tmc.edu     (713) 798-3892    Web Link    Lab Webpage    Neuroimaging, Magnetic Resonance, Medical Imaging, Alzheimer's Disease, Brain Imaging, 3D-Imaging, Diffusion Magnetic Resonance Imaging, Mouse Models, Molecular Imaging, Magnetic Resonance Imaging, Image Post-Processing, Tractography, Small Animal Imaging    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   Dr. Pautler develops and applies methodologies that permit high- resolution images of the structure and function of the brain in intact, living animals. Her current research efforts build upon the new technique that she developed known as Manganese Enhanced MRI (MEMRI) neuronal tract tracing. Manganese ion, Mn2+, is a calcium analogue and can enter neurons through calcium (Ca2+) channels. Furthermore, Mn2+ is transported along microtubules via fast axonal transport and is also paramagnetic, rendering it MRI detectable in spin-lattice (T1)-weighted MRI images. It is therefore possible to utilize MRI to repeatedly measure dynamic changes in signal intensity, reflective of fast axonal transport of Mn2+ ion, within the same animal before and during disease progression. One main project in Dr. Pautler's lab involves utilizing MEMRI to longitudinally elucidate in vivo changes in axonal transport rates in the central nervous system of mouse models of Alzheimer's Disease (AD) as symptoms evolve. Axonal transport deficits have been observed in flies and cultured rodent neurons exposed to excess amyloid precursor protein (APP) or amyloid-beta, but neither the molecular basis of the transport deficit nor the temporal relationship of the transport deficit and the acquisition of AD are known.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia John S. Dunn, Sr. GCC for Magnetic Resonance  Training Grants Houston Area Molecular Biophysics Training Program  Research Consortia Gulf Coast Cluster for NeuroEngineering Gulf Coast Cluster for Translational Imaging  Training Grants Houston Area Molecular Biophysics Training Program  Appointments Title Department / School Institution Professor Molecular Physiology Baylor College of Medicine

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