Gu, Yanping (Faculty Profile)

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Faculty Profile

Last Modified Time: 08:05:36 AM Tue, 7 Apr 2020

Contact Information
Yanping Gu	Associated Profiles
Assistant Professor, Neuroscience and Cell Biology, UT Medical Branch at Galveston

Mail Box: 1069
yagu@utmb.edu 409-772-6555 Web Link
Spinal Ganglia, Purinergic P2X3 Receptors, Neurons, N-Methyl-D-Aspartate Receptors, Dynorphins, Nociceptors, Mu Opioid Receptor, N-Methylaspartate

Research and Expertise
Affiliations
Appointments

Research and Expertise

Research Interests

My research interests focus on the cellular and molecular mechanisms of chronic pain and genetic approaches for the treatment of pain. Using inflammation and nerve injured rats as chronic pain models I have studied the injury-induced modulation of glutamate and purinergic P2X receptor-mediated responses by second messengers, including Ca2+, nitric oxide, protein kinases and peptides. I also introduced adeno-associated viral vectors which carried the mu-opioid receptor gene (rAAV-MOR) into the dorsal root ganglia of these animals. This manipulation produced a long-lasting up-regulation of MORs in DRG neurons and greatly potentiated the antinociceptive effects of morphine. The information obtained from these studies helps us better understand the mechanisms underlying pain processing and suggests new therapeutic approaches to pain relief.

Publications/Creative Works

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Affiliations

Research Consortia

Gulf Coast Cluster for Translational Pain Research

Appointments

Title	Department / School	Institution
Assistant Professor	Neuroscience and Cell Biology	UT Medical Branch at Galveston

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