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Faculty Profile Last Modified Time: 11:14:21 AM Mon, 6 Apr 2020   Contact Information Michael A Davies Associated Profiles  Chair, Professor, Melanoma Medical Oncology, UT MD Anderson Cancer Center   MDA FC11.3028, Room No.: Unit 0430    MDavies@mdanderson.org     713-792-3454    Web Link    Melanoma, Neoplasms, Mutation, Therapeutics, Neoplasm Metastasis, Mitogen-Activated Protein Kinase Kinases, Survival, Phosphatidylinositol 3-Kinase    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   My laboratory studies the regulation and functional role of kinase signaling pathways in melanoma, which is the most aggressive form of skin cancer. We utilize a number of methods, including reverse phase protein arrays (RPPA), transcriptional profiling, and DNA sequencing, to allow for efficient and broad assessment of protein signaling networks. For clinical specimens, we use these and other methods to determine clinical and pathological correlates of different mutations and signaling pathway activation, including in patients treated with molecularly targeted therapies. In vitro, we use these methods to identify predictors of sensitivity and resistance to therapeutic agents. We also study the changes in protein and gene expression networks induced by different therapies to identify mechanisms of resistance, in order to develop rational, more effective combinatorial approaches. We also have a specific effort to understand the molecular biology of, and rational therapeutic approaches for, brain metastases.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia John S. Dunn GCC for Chemical Genomics  Appointments Title Department / School Institution Chair, Professor Melanoma Medical Oncology UT MD Anderson Cancer Center

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