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Faculty Profile Last Modified Time: 09:24:08 AM Mon, 20 Apr 2020   Contact Information Shuxing Zhang Associated Profiles  Associate Professor, Experimental Therapeutics, UT MD Anderson Cancer Center, Adjunct Professor, School of Biomedical Informatics, UT Health Science Center at Houston   MDA 3SCR4.4107, Room No.: Unit 1950    shuzhang@mdanderson.org     713-745-2958    Web Link    Drug Discovery, Neoplasms, Thiamine Deficiency, Polypharmacology, Computer Simulation, MicroRNAs, Drug Design, Phosphotransferases    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   The research in my laboratory is dedicated to computer-assisted drug design and discovery, mainly in two disciplines: cheminformatics and bioinformatics. A strong interest is to develop active agents for targeted cancer therapy. We have been working on various targets, including Akt, TRAF6, Skp2, PKM2, microRNAs, etc. Another focus is to develop novel computational methods and strategies that are urgently needed for drug discovery and development. More specifically, we are interested in developing novel QSAR methods (machine learning and molecular descriptors), molecular docking/scoring functions, drug polypharmacology and multi-targeting agent design approaches, ADMET predictors, and high-performance computing-based virtual screening strategies. In addition, we are interested in protein bioinformatics, in particular protein design and engineering. By studying the protein structure, we could delineate the critical residues in proteins for their functions, and thus generate testable hypotheses for experimental validations such as site-directed mutagenesis studies.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia John S. Dunn GCC for Chemical Genomics  Appointments Title Department / School Institution Associate Professor Experimental Therapeutics MD Anderson Cancer Center

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