Tweardy, MD, David J. (Faculty Profile)

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Faculty Profile

Last Modified Time: 11:14:02 AM Wed, 12 May 2021

Contact Information
David J. Tweardy, MD	Associated Profiles
Division Head, Internal Medicine, and Professor, Infectious Diseases and Molecular and Cellular Oncology, MD Anderson Cancer Center


djtweardy@mdanderson.org Faculty Profile Lab Webpage
Hemorrhagic Shock, Granulocyte Colony-Stimulating Factor, Interleukin-6, STAT3 Transcription Factor, Granulocyte Colony-Stimulating Factor Receptors, Messenger RNA, Cell Line, Neoplasms

Research and Expertise
Affiliations
Appointments

Research and Expertise

Research Interests

I am a physician-scientist with a career-long interest in the host response to microbial and traumatic injuries and to oncogenesis. I am recognized for my expertise in inflammation and apoptosis, in particular, my contributions to our understanding of cytokine signaling and STAT protein structure and function to these processes. My colleagues and I are using Stat3 inhibitors developed by my group as chemical probes to interrogate the contribution of Stat3 to cancer and chronic inflammatory diseases and are exploiting insights gained into Stat3 proteostasis to develop novel therapies for autosomal dominant hyper-IgE (Job's) syndrome and other immunodeficiencies caused by destabilizing point mutations in STAT proteins.

Publications/Creative Works

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Affiliations

Research Consortia

John S. Dunn GCC for Chemical Genomics

Training Grants

Computational Cancer Biology Training Program

Appointments

Title	Department / School	Institution
Division Head	Internal Medicine	MD Anderson Cancer Center

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