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Faculty Profile Last Modified Time: 11:55:50 AM Fri, 12 Jul 2024   Contact Information Bert W. O'Malley Associated Profiles  Chancellor, Molecular and Cell Biology, Baylor College of Medicine     One Baylor Plaza        berto@bcm.tmc.edu     713-798-6205    Web Link    Hormone Action, Coactivator Function, Eukaryotic Gene Expression, Gene Therapy, Nanotechnology    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   Dr. Bert O'Malley, professor of molecular and cell biology, has focused his research on the molecular mechanisms that guide gene regulation in endocrinology and endocrine cancers. His work has improved our understanding of the molecular mechanisms by which hormones, receptors and coactivators contribute to the disease process. His pioneering work in this field has shown that intracellular hormones and cofactors act at the level of DNA to regulate the production of proteins and affect the function of the cell. Recent research reported in Molecular Cell was the first to solve the structure of a functional receptor-coactivator complex on DNA capable of regulating gene transcription in vitro. In addition, in a paper published in the Journal of Clinical Investigation, he showed that steroid receptor coactivator-2 (SRC-2), which is highly elevated in a variety of tumors, is likely implicated in metabolic coordination of cancer metastasis, opening the possibility of therapeutically targeting the SRC-2 pathway. His work with steroid receptor coactivator-3 (SRC-3), a prognostic marker for aggressive human breast cancer, showed that small-molecule inhibitors that directly bind SRC-3 cause selective degradation of the complex, hereby killing cancer cells with no observable toxicity. Small-molecule inhibitors represent a new type of oncologic drugs that target coactivators.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Training Grants Training Interdisciplinary Pharmacological Scientists  Research Consortia John S. Dunn GCC for Chemical Genomics  Training Grants Training in Precision Environmental Health Sciences (TPEHS)  Research Consortia Gulf Coast Cluster for Single Cell Omics  Appointments Title Department / School Institution Chancellor Molecular and Cell Biology Baylor College of Medicine

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