Image Cytometry, Quantitative Microscopy, Digital Pathology, High Content Screening/Assays, High-Speed Scanning, 3D Cytometry, High Throughput Confocal Microscopy
The central theme is creation of high performance of image cytometry (AKA, quantitative microscopy, digital pathology, high content screening / assays – HCS/A) instrumentation and algorithms. The instrumentation focus areas include high performance autofocus, high-speed scanning, 3D cytometry and high throughput confocal microscopy. We apply these advances to: genomic and compound HCS/A (for early drug discovery and toxicity); kinetics of fast cellular events (including muscle contraction, cardiomyocyte arrhythmogenicity, neuron action potentials, ²-cell insulin release); tracking of cell migration, development/differentiation and cancer progression; ultra-rare circulating tumor cell biology; and histology of cancer biomarkers.
Publications/Creative Works
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