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Faculty Profile Last Modified Time: 10:58:32 AM Fri, 18 Jun 2021   Contact Information Stephen Safe Associated Profiles  Distinguished Professor, Veterinary Physiology and Pharmacology, Biochemistry and Biophysics, Syd Kyle Chair, Veterinary Medicine, Texas A&M University   Mail Box: 4466, Veterinary Research Building, Room No.: 140    ssafe@cvm.tamu.edu     979-845-5988    Web Link    Cancer Cells, Hepatocellular Carcinoma, Lipids, Environmental Toxicology, Gas Chromatography, Petroleum, Fatty Acids, Biotransformation, Lipid Analysis, Environmental Health, PCB, Polychlorinated Biphenyls, Sterols, Drug Transport    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   The aryl hydrocarbon receptor (AhR) is a nuclear helix-loop-helix transcription factor which forms a ligand-induced nuclear heterodimer with the AhR nuclear translocator (Arnt) protein. Research in this laboratory is focused on the molecular mechanism of crosstalk between the AhR and estrogen receptor (ER) signaling pathways in which the AhR inhibits estrogen-induced gene expression. The antiestrogenic activities of some AhR agonists are also being developed as drugs for clinical treatment of breast and endometrial cancers in women. Research on estrogen-dependent gene expression in various cancer cell lines is focused on analysis of several gene promoters to determine the mechanisms of ERa and ERb action. This includes several genes that are activated through interactions of the ER with Sp1 protein and other DNA-bound transcription factors.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia John S. Dunn GCC for Chemical Genomics  Training Grants The Cancer Therapeutics Training Program (CTTP)  Appointments Title Department / School Institution Distinguished Professor Veterinary Physiology and Pharmacology Texas A&M University

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