Dr. Mancinci has been a pioneer in the development and application of high throughput microscopy (HTM) to quantitative analysis of cell function and to drug discovery research. These studies have led to the development of a novel, fully automated "ultra"-HCA approach to that can be applied to small molecule and RNAi screening applications. Dr. Mancini's laboratory uses high resolution light microscopy, time lapse studies, and biophysical measurements of nuclear protein mobility to develop single cell assays to study the activity of steriod receptors and receptor co-regulators in breast and prostate cancer cells.
Publications/Creative Works
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