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Faculty Profile Last Modified Time: 12:10:41 PM Thu, 8 Dec 2022   Contact Information Andres Oberhauser, PhD Associated Profiles  Professor, Neuroscience and Cell Biology, UT Medical Branch at Galveston   Mail Box: 06203, Research Building 17, Room No.: 5.212A    afoberha@utmb.edu     409-772-1309     409-747-2187    Faculty Profile    Research Web Page    Atomic Force Microscopy, Elasticity, Connectin, Proteins, Mast Cells, Secretory Vesicles, Protein Engineering, Mechanical Stability    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   Our lab is interested in the mechanism by which proteins respond to mechanical forces. A large fraction of the proteins have structural and thus also mechanical functions. Examples include muscle proteins (e.g. titin), cytoskeletal proteins (e.g. spectrin) and proteins of the extracellular matrix (e.g. fibronectin). However, not much is known how single proteins respond to mechanical forces. Do they behave as simple springs or do they display more complex features? Do they share common set of design principles and mechanical fingerprints? We are currently studying the mechanical properties of elastin (an abundant component of connective tissue), polycystin-1 (a cell membrane receptor found mainly in kidney tubules) and projectin and twitchin (titin-like protein found in Drosophila and C. elegans). We hypothesize that these proteins function as a mechanical sensors that regulates several processes, including cell growth and tissue morphogenesis. We are testing this hypothesis by directly measuring their mechanical properties using novel Atomic Force Microscopy (AFM) techniques that are capable of tracking forced-induced conformational changes in single molecules.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia GCC Cluster for Cellular and Molecular Biophysics  Appointments Title Department / School Institution Professor Neuroscience & Cell Biology UT Medical Branch at Galveston

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