Javascript must be enabled to use this form.

View Profile	Home Browse Faculty Facility Research Consortia Training Grants Courses Search Support About rSp Help and FAQ's Contact Us	GCC Home
Faculty Profile Last Modified Time: 02:36:44 PM Thu, 7 Mar 2024   Contact Information Aleksandar Milosavljevic Associated Profiles  Henry and Emma Meyer Chair in Molecular Genetics, Director - Program in Quantitative and Computational Biosciences, Co-Director - Computational and Integrative Biomedical Research Center, Baylor College of Medicine   Mail Box: BCM225, One Baylor Plaza, Room No.: Suite 400D    amilosav@bcm.edu     713-798-8719    Web Link    Lab Webpage    Genomics, Cancer Genomics, Bioinformatics, Epigenomics, DNA, Bioinformatics and Computational Biology    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   The Bioinformatics Research Laboratory (BRL), directed by Dr. Milosavljevic, develops new computational methods and discovery systems, with ongoing projects in genomics, epigenomics, extracellular RNA communication and tumor biology. The Genboree System is the largest software system developed at BRL. Genboree Workbench contains over two hundred software tools and utilities organized into toolsets for genomic, epigenomic, transcriptomic, and metagenome analysis. The Extracellular RNA Communications Consortium and a number of collaborative projects use Genboree as their core informatic infrastructure. As part of the NIH Roadmap Epigenomics Initiative, the laboratory constructed a human epigenome atlas that maps cell-type specific epigenetic programs and identifies markers of cellular identity. This information is currently being applied to better understand the biology of human tumors, specifically the diversity of cell types within tumors and their interactions during cancer progression. As part of the NIH Extracellular RNA Communication Consortium, the laboratory is constructing an atlas of extracellular RNAs involved in intercellular communication. One specific area of interest are the interactions of epithelial, stromal and immune cells within tumors that are mediated my microRNAs. This information will translate into therapies that target intercellular communication and "liquid biopsy" biomarkers that may be found in human body fluids. The laboratory is involved in analysis of genome variation in human health and disease. As part of the Clinical Genome Resource project, the laboratory is developing a Pathogenicity Calculator to aid the interpretation of human genome variation in clinical contexts. One specific focus is on the identification of actionable variants discovered upon genome sequencing. The origins and the impact of genetic variation within the (98.5%) fraction of the genome that does not code for protein sequence is currently very limited. We believe that this knowledge will emerge in large part from the study of interactions between genomic and epigenomic variation. Using the reference epigenomes in the human epigenome atlas, we have recently established an association between structural mutability of the human genome and hypomethylation in human germline. We are expanding these studies to better understand interactions between the epigenome and genomic instability not only in human germline but also in human somatic cells and in cancer, with a focus on highly rearranged genomes found in breast, ovarian, prostate, and brain cancer.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Training Grants Training in Precision Environmental Health Sciences (TPEHS) NLM Training Program in Biomedical Informatics & Data Science for Predoctoral and Postdoctoral Fello  Appointments Title Department / School Institution Professor Molecular and Human Genetics Baylor College of Medicine

powering - The Partnership
Important Disclaimer: The responsibility for the accuracy of the information contained on these pages lies with the authors and user providing such information.