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Faculty Profile Last Modified Time: 10:01:23 AM Tue, 7 Apr 2020   Contact Information Ruth Heidelberger Associated Profiles  Professor, Neurobiology and Anatomy, Frederic B. Asche Chair, Ophthalmology, UT Health Science Center at Houston   Medical School Extension, Room No.: R426    Ruth.Heidelberger@uth.tmc.edu     713.500.5624    Web Link    Lab Webpage    Exocytosis, Synapses, Synaptic Vesicles, Presynaptic Terminals, Calcium, Goldfish, Endocytosis, SNARE Proteins    Associated Profiles Research and Expertise Appointments  Research and Expertise Research Interests   The research in my laboratory is directed at understanding the mechanisms that underlie and regulate neurotransmitter exocytosis. As a model system, we study exocytosis in bipolar neurons isolated from vertebrate retina. These neurons have unusually large presynaptic terminals that allow us to place an electrode directly onto the presynaptic ending to electrically monitor synaptic vesicle fusion and recovery in real-time. As a second model system, we work with neuroendocrine cells of the adrenal medulla. The use of these two model systems allows us to study and compare exocytosis of small, clear-core synaptic vesicles (bipolar cells) with exocytosis of large, dense-core granules (adrenal chromaffin cells). Current studies are directed at understanding the role of ATP in neurotransmitter release and synaptic vesicle cycling and at identifying presynaptic sites of regulation and modulation of exocytosis. The role of local retinal circuit interactions on neurotransmitter release and the consequences of this modulation on visual processing are also considered.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Appointments Title Department / School Institution Professor Neurobiology and Anatomy UT Health Science Center Houston

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