Javascript must be enabled to use this form.

View Profile	Home Browse Faculty Facility Research Consortia Training Grants Courses Search Support About rSp Help and FAQ's Contact Us	GCC Home
Faculty Profile Last Modified Time: 09:19:44 AM Tue, 7 Apr 2020   Contact Information Mike Gustin Associated Profiles  Professor, BioSciences, Rice University   George R. Brown Hall, Room No.: W200G    gustin@rice.edu     713-348-5158    Web Link    Molecular Genetics, Biochemistry of Signal Transduction, Cell Stimuli, Saccharomyces Cerevisiae, Osmolarity, Signaling Pathways, Osmosensing, Transcriptional Regulation, Osmotic Stress-Induced Cell Cycle Delay    Associated Profiles Research and Expertise Appointments  Research and Expertise Research Interests   A fundamental problem in biology is how cells sense and respond to stimuli such as changes in pressure, osmolarity, or mechanical forces. Most of our research employs the yeast Saccharomyces cerevisiae as a model system for understanding the molecular mechanisms required for sensing and responding to changes in external osmolarity and other stresses. Genetic and biochemical analysis of mutants that fail to grow in high (or low) osmolarity media has allowed us to uncover two stress-activated signaling pathways, the hog and cell intensity pathways, respectively. Both of these pathways contain a unique map kinase cascade. We are currently investigating the mechanism of osmosensing and transcriptional regulation by these pathways plus their role in osmotic stress-induced cell cycle delay. A pathway similar to the yeast hog pathway is found in osteoblasts, mammalian cells not usually exposed to osmotic stress. We are therefore investigating the role of the hog pathway in responses of these cells to mechanical stress. In addition, my research group, in collaboration with Dr. Mikos (Bioengineering, Rice U.), is examining the function of the mammalian hog pathway in mediating activation of bone forming cells by mechanical stress.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Appointments Title Department / School Institution Professor BioSciences Rice University

powering - The Partnership
Important Disclaimer: The responsibility for the accuracy of the information contained on these pages lies with the authors and user providing such information.