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Faculty Profile Last Modified Time: 03:33:15 PM Thu, 31 Aug 2023   Contact Information Peter J Davies Associated Profiles  Professor and Director, Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M Health Science Center   1201 TAMUS    pdavies@tamu.edu     713-677-7474    Web Link    Translational Research, Cancer, Pharmacology, RXR    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   Retinoids are a group of naturally occurring metabolites of Vitamin A that exert profound effects on the growth and differentiation of malignant cells. Our studies have demonstrated that a specific retinoid, trans-retinoic acid, has a direct effect on the rate of expression of a specific enzyme, tissue transglutaminase, in normal and leukemic macrophages. We are using the expression of tissue transglutaminases to characterize the molecular steps involved in the interactions of retinoic acid with a target cell. Specifically, we are investigating how retinoids are delivered to susceptible cells, how the retinoids reach the nucleus and how they interact with chromatin to regulate gene expression. We hope from these studies to establish the role of retinoids in the regulation of proliferation of both normal and leukemic cells. Research Interests    Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia John S. Dunn GCC for Chemical Genomics  Training Grants The Cancer Therapeutics Training Program (CTTP)  Appointments Title Department / School Institution Professor and Director Center for Translational Cancer Research Institute of Biosciences and Technology, Texas A&M Health Science Center

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