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Faculty Profile Last Modified Time: 10:28:18 AM Wed, 1 Apr 2020   Contact Information Wlodzimierz Bujalowski Associated Profiles  Professor, Biochemistry & Molecular Biology, UT Medical Branch at Galveston   Mail Box: 1053, Medical Research Building, Room No.: 5.138D    wbujalow@utmb.edu     (409) 772-5634    Web Link    DnaB Helicases, Escherichia Coli, Single-Stranded DNA, Nucleotides, Binding Sites, DNA, Fluorescence, Proteins    Associated Profiles Research and Expertise Appointments  Research and Expertise Research Interests   Great interest in the mechanism by which proteins interact with nucleic acids results from the extreme importance of these interactions for many vital cellular processes including replication, recombination, repair, transcription and translation. We have a long-term interest in quantitative understanding of the structure-function relationships in protein-nucleic acid interactions in solution. Such understanding can be achieved through rigorous thermodynamic, kinetic, and structural (spectroscopic) studies of both macromolecules and their relevant complexes. The current major projects in our laboratory focus on: 1.Quantitative molecular understanding of the mechanism of a replicative helicase. 2.Quantitative determination of the mechanism of DNA substrate recognition by a DNA polymerase. Both helicases and polymerases are two classes of essential enzymes involved in DNA metabolism. Part of our work is directed toward development novel rigorous quantitative methods to study thermodynamics and kinetics of complex macromolecular interactions in solution using powerful spectroscopic techniques which include steady-state and life-time fluorescence spectroscopy, fluorescence energy transfer and anisotropy techniques, analytical ultracentrifugation, dynamic light scattering, fast chemical kinetics, and various other biochemical methods.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Appointments Title Department / School Institution Professor Biochemistry and Molecular Biology UT Medical Branch at Galveston

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