Professor and Chief, Medicine-Epidemiology & Population Sciences, Associate Director of Quantitative Science, Director for the Institute of Clinical and Translational Medicine, Baylor College of Medicine
DNA Sequencing, Sequencing, Genomics, Bioinformatics and Computational Biology, Next Generation Sequencing, Genetic Analysis, Human Genetics, Single Nucleotide Polymorphism, Quantitative Genetics, Statistical Genetics, Phenotyping
My interest in understanding the biological processes that influence complex disease and cancer development. The development of new approaches of genetic analysis was leading to an explosion in the need for mathematical modeling and information technologies. The ability to work at a crossroads of biology and statistics allowed me to develop new approaches for understanding cancer etiology. New technologies and approaches to modeling are giving us great insights into the joint effects of environmental and genetic contributions to the causes of cancer. The ability to profile hundreds of thousands of cancer cases and controls has given us thousands of new insights and has allowed us to identify, through mediation and Mendelian randomization approaches, a great diversity of new candidates, influencing early stages of cancer development. These observations will lead to a much more precise knowledge of the key steps that influence the development of all common cancers.
Publications/Creative Works
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Affiliations
Training Grants
Training in Precision Environmental Health Sciences (TPEHS)
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