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Faculty Profile Last Modified Time: 11:31:20 AM Fri, 17 Apr 2020   Contact Information Ah-Lim Tsai Associated Profiles  Professor, Hematology, UT Health Science Center at Houston     Ah-Lim.Tsai@uth.tmc.edu     713-500-6771    Web Link    Chemical Reaction Engineering, Kinetics, Enzymology, Free Radicals, Mitochondria, Chemical Kinetics, Nitric Oxide, Biocatalysis, Enzyme Catalysis, Nitric Oxide Synthase, Electron Transfer, Reaction Mechanisms, Electron Spin Resonance Spectroscopy    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   The central theme of my research is to understand the reaction mechanism of several crucial heme-containing proteins that are involved in regulatory functions and the pathological processes of the cardiovascular system. Prostaglandins and nitric oxide (NO) are two important mediators in hemostasis. For example, prostacyclin and NO released by endothelial cells are strong vasodilators and potent inhibitors of platelet aggregation, whereas thromboxane and prostaglandin G2/H2 released by platelets are potent agonists of platelet aggregation and vasoconstriction. All these compounds are short-lived autocoids. A balanced production and timely release of these potent hormones are crucial in maintaining a normal vascular tone and an imbalanced synthesis of these mediators usually leads to pathological conditions.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia John S. Dunn GCC for Chemical Genomics John S. Dunn, Sr. GCC for Magnetic Resonance  Training Grants Houston Area Molecular Biophysics Training Program  Research Consortia GCC Cluster for Cellular and Molecular Biophysics  Appointments Title Department / School Institution Professor Hematology UT Health Science Center Houston

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