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Faculty Profile Last Modified Time: 02:42:48 PM Thu, 16 Apr 2020   Contact Information John Putkey Associated Profiles  Professor, Vice Chair, BCB Graduate Program, UT Health Science Center at Houston   Medical School Building, Room No.: 6.172    John.Putkey@uth.tmc.edu     713-500-6061    Web Link    Calmodulin, Troponin C, Calcium, Chickens, Vitamin D, Binding Sites, Muscle, Microvilli    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   Calcium plays an essential role as a structural element and as a second messenger in the regulation of an array of cellular processes. However, the calcium ion itself encodes no intrinsic information. The cellular signal represented by fluctuations in calcium ion concentrations must be interpreted by specific calcium-binding proteins which act to regulate the activity of other enzymes or proteins. The importance of proteins that bind calcium is underscored by the lethality of disrupting these genes in transgenic mice, and genetic diseases which result from mutations in genes that encode calcium binding proteins. Thus, an understanding of structure/function relationships in calcium binding proteins would provide unique insights into the structural basis of diseases, and provide a data base of information for the development of drugs that can alter the properties of regulatory calcium binding proteins. My laboratory applies a synergistic blend of molecular and structural biology to study the molecular anatomy of calcium binding proteins. Current projects focus on cardiac troponin C, calmodulin, and cartilage oligomeric matrix protein (COMP). Areas of interest include: The mechanisms of regulation of calmodulin activity by post-translational modification and modulation of calmodulin binding to target proteins; Exploring the molecular mechanism of regulation of cardiac muscle contraction by calcium binding to cardiac troponin C, and how cardio-tonic drugs lead to an increased efficiency of cardiac muscle contraction; Using NMR to reveal the structural basis behind why mutations in the extracellular matrix protein COMP lead to skeletal dysplasia and dwarfing syndromes.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia John S. Dunn, Sr. GCC for Magnetic Resonance  Training Grants Houston Area Molecular Biophysics Training Program  Research Consortia GCC Cluster for Cellular and Molecular Biophysics  Appointments Title Department / School Institution Professor Biochemistry and Molecular Biology UT Health Science Center Houston

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