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Faculty Profile Last Modified Time: 11:00:03 AM Wed, 11 Sep 2024   Contact Information Alessandro Bonifazi Associated Profiles  Associate Professor, Pharmacology and Toxicology - Center for Addiction Sciences and Therapeutics, UT Medical Branch at Galveston     albonifa@utmb.edu    Web Link   List of Publications    Medicinal Chemistry; Organic Synthesis; Chirality in Drug Design    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Pharmaceutical Sciences Università degli Studi di Camerino 2014  MS/PharmD Pharmaceutical Chemistry and Technology Università degli Studi di Camerino 2010  Research and Expertise Research Interests   Our primary research goals are directed toward the design, synthesis, and development of small molecules as pharmacological tools for neuroscience applications and potential therapeutics. Specifically, we primarily target G protein-coupled receptors (GPCRs). Our work in medicinal chemistry contributes to drug discovery campaigns, particularly in the fields of biased agonism/functional selectivity and poly-pharmacology. We aim to create novel ligands that facilitate the understanding of cross-pharmacological modulation in receptors. Additionally, we investigate receptors’ pathway activations at the molecular level, elucidating their roles in the (patho)-physiology of the central nervous system (CNS). We strive in providing molecules to uncover ligand-receptor interactions, identify unique active and/or inactive receptor conformations, providing valuable insights into cellular processes.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia Gulf Coast Consortium for Mental Health Research John S. Dunn Gulf Coast Consortium for Innovative Drug Discovery and Development  Appointments Title Department / School Institution Associate Professor Pharmacology and Toxicology - Center for Addiction Sciences and Therapeutics UT Medical Branch at Galveston

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