Our basic research interests focus on the impact of probiotics in neonatal GI-related diseases and autoimmune disorders; the mechanism of probiotics in regulating immunity, modulating gut microbiota and microbial-associated metabolites; the effects of probiotics in gut-brain axis; and the effect of human breast milk factors on the function of probiotics. Our basic research lab also involves in clinical research projects including the completed study of the effect of probiotic Lactobacillus reuteri on infantile colic, and ongoing "Road to discovery for combination probiotic BB-12 with LGG in treating autism spectrum disorder". We process patient samples, analyze the circulating immune cells, plasma and fecal inflammatory biomarkers, gut permeability markers, and stool DNA isolations for gut microbiota analysis, monitoring the quality of probiotic products by measuring how many CFUs in the probiotic product. We also support GI fellows' research projects including assisting IRB protocol preparation (lab-related contents), study design, sample processing, assay, and analysis.
Publications/Creative Works
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