The University of Manchester Institute of Science & Technology
2003
Research and Expertise
Research Interests
Dr. Shepherd is interested in understanding the impact of neuroimmune interactions in chronic pain states. It has been shown that macrophages can profoundly affect the progression of nerve injury and the associated pain. These processes can be influenced by pre-existing systemic inflammation, such as that seen in obesity and certain types of cancer.
Dr. Shepherd engages in pre-clinical research to elucidate the mechanisms that link inflammation to pain induced by various forms of injury, including joint damage and chemotherapy-induced neuropathy, with a particular focus on signaling related to the renin-angiotensin system. The ultimate goal of this research is to identify interventions that can mitigate or prevent the development of pain associated with these chronic disease states.
Publications/Creative Works
Click here to search for this faculty member's publications on PubMed.
Important Disclaimer: The responsibility for the accuracy of the information contained on these pages lies with the authors and user providing such information.