Li, Ziyin (Faculty Profile)

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Faculty Profile

Last Modified Time: 03:16:33 PM Tue, 25 May 2021

Contact Information
Ziyin Li	Associated Profiles
Professor, Microbiology and Molecular Genetics, UT Health Science Center at Houston

Medical School Extension Building, Room No.: R224
Ziyin.Li@uth.tmc.edu 713-500-5139 Web Link Lab Webpage
Gel Electrophoresis, Yeast Genetics, Cloning, PCR, Co-Immunoprecipitation, Immunofluorescence Microscopy

Professional Preparation
Research and Expertise
Affiliations
Appointments

Professional Preparation

Degree	Major	Institution	Year
PhD	Molecular Genetics	Chinese Academy of Sciences	2000

Research and Expertise

Research Interests

My laboratory is mainly interested in understanding the molecular mechanism of mitosis and cytokinesis. We use Trypanosoma brucei, a unicellular eukaryote and the causative agent of human sleeping sickness, as a model organism to address the fundamental questions of how mitosis and cytokinesis are regulated and coordinated during cell division. The current focus is on the cell cycle regulatory pathways consisting of protein kinases such as Aurora B kinase, Polo-like kinase and Tousled-like kinase, spindle-associated motor proteins, and ubiquitin ligases.

We are also interested in the role of ubiquitin-dependent and -independent proteolysis in various cell biological processes. ATP-dependent protease complexes are present in all three kingdoms of life where they ride the cell of mis-folded or damaged proteins and control the level of certain regulatory proteins. These proteases include the 26S proteasome in eukaryotes, Archaea, and Actinomycetales and the HslVU protease in eubacteria. The current focus is on three proteolytic pathways: the Cullin-RING ubiquitin ligase (CRL) and the anaphase-promoting complex/cyclosome (APC/C) on cell cycle control and the HslVU protease on mitochondrial DNA replication.

We use a combination of genetics, biochemistry, cell biology, molecular biology, chemical genetics, and proteomics to elucidate the molecular and cellular basis of cell cycle control in trypanosomes. We hope to provide a few drug targets for anti-trypanosome chemotherapy.

Publications/Creative Works

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Affiliations

Training Grants

Molecular Basis of Infectious Diseases Training Grant

Appointments

Title	Department / School	Institution
Professor	Microbiology and Molecular Genetics	UT Health Science Center at Houston

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