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Faculty Profile Last Modified Time: 02:43:48 PM Fri, 29 Jan 2021   Contact Information Seyed Moghaddam Associated Profiles  Associate Professor, Pulmonary Medicine, UT MD Anderson Cancer Center     smoghadd@mdanderson.org     713-792-0761    Web Link    Lab Webpage    Lung Neoplasms, Chronic Obstructive Pulmonary Disease, Carcinogenesis, Lung, Haemophilus Influenzae, Inflammation, Pulmonary Diseases, Neoplasms    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  MD Medicine Shaheed Beheshti University of Medical Sciences 1996  Research and Expertise Research Interests   My research is focused on airway inflammation and its role in airway epithelial carcinogenesis. Tumor-promoting inflammation is a cancer hallmark, and it is considered an enabling characteristic due to its contributions to the acquisition of core hallmark capabilities. Cigarette smoking is the principal cause of lung carcinogenesis. However, several studies have found that smokers with chronic obstructive pulmonary disease (COPD), an inflammatory disease of the lung, have an increased risk of lung cancer compared to smokers with comparable cigarette exposure but without COPD. This suggests a strong link between COPD-related airway inflammation and lung cancer. In addition, it is known that mutant epithelial cells begin to edit the microenvironment as soon as they transform but the exact mechanisms involved in this immuno-editing process from escaping the immunosurveillance to tumor progression still not well understood. We have previously shown that the numerous cytokines released during inflammation (oncogene-driven or COPD-related) promote lung tumorigenesis in a genetic mouse model of lung cancer. We are currently dissecting the sex- and cell-type specific mechanisms responsible for this phenomenon with genetic and pharmacologic approaches. This will provide a better understanding of the role of specific inflammatory pathways in lung carcinogenesis, and subsequently allow preclinical testing of the efficacy of anti-inflammatory agents in preventing lung cancer in high-risk population or patient with early metaplastic lesions. This would also have a major impact on the treatment of patients with lung cancer by providing the basis for rationally directed immunotherapeutic modalities to improve the efficacy of currently available treatment regimens.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia Gulf Coast Consortia Immunology Cluster  Appointments Title Department / School Institution Associate Professor Pulmonary Medicine UT MD Anderson Cancer Center

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