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Faculty Profile Last Modified Time: 03:38:21 PM Fri, 23 Oct 2020   Contact Information Munmun Chattopadhyay Associated Profiles  Associate Professor, Center of Emphasis in Diabetes and Metabolism, Texas Tech Health Science Center El Paso     munmun.chattopadhyay@ttuhsc.edu     915-215-4170    Web Link    DNA, Neurotrophic Factors, Genetics, GABA, Neuron, Nerve Growth Factor, NGF    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Neurosciences Jiwaji University    MSc Zoology Jiwaji University    BSc Biology, Zoology University of Calcutta    Research and Expertise Research Interests   My research focus is to demonstrate the impact of inflammatory mediators on the pathogenesis of diabetic complications: neuropathy, nephropathy and gastroparesis. We have established that replication defective herpes simplex virus-mediated gene transfer of growth factors (NGF, NT-3, VEGF) can prevent diabetic and drug-induced peripheral sensory neuropathy in animals, and that gene transfer mediated release of inhibitory neurotransmitters (Enkephalin, GABA) in diabetic animals reduces pain concomitantly with a reduction in sodium channel NaV1.7 levels in dorsal root ganglion (DRG). Our recent studies show therapeutic benefits of HSV mediated release of anti-inflammatory mediators (IL-10, sTNFR) in the DRG with a reduction of pro-inflammatory cytokines, subsequently inhibiting painful neuropathy. We have also demonstrated exercise-mediated alleviation of painful neuropathy with a decrease in neuro-inflammation. Currently we are assessing if blocking the release of noxious cytokines improves renal dysfunction and gastric dys-motility in diabetic animals. We are trying to identify novel early biomarkers of inflammation and epigenetic modulators (histone modifications) involved in the progression of neuropathy, nephropathy and gastroparesis in diabetic animals, and are exploring whether inhibiting inflammation or epigenetic changes will alter the progression of these complications. Thus, we are focusing on understanding the role of inflammation and nutritional deficits in the development of diabetic complications and co-morbidities.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia Gulf Coast Consortium for Translational Pain Research  Appointments Title Department / School Institution Associate Professor Center of Emphasis in Diabetes and Metabolism Texas Tech Health Science Center El Paso

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