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Faculty Profile Last Modified Time: 03:33:40 PM Tue, 15 Sep 2020   Contact Information Helen Heslop Associated Profiles  Dan L. Duncan Chair, Director, Center for Cell and Gene Therapy, Professor, Medicine and Pediatrics, Baylor College of Medicine   Feigin Center, Room No.: TXFC-164006    hheslop@bcm.edu     (832) 824-4671    Web Link    Cell and Gene Therapy, Bone Marrow Transplant, Stem Cell Transplant, Cytotoxic T-Lymphocytes, Adoptive Immunotherapy, T-Lymphocytes, Human Herpesvirus 4, Epstein-Barr Virus Infections    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  MD Immunology University of Otago 1990  Research and Expertise Research Interests   Helen Heslop is a physician-scientist engaged in translational research focusing on adoptive immunotherapy with gene-modified effector cells, to improve hemopoietic stem cell transplantation and cancer therapy. A key step in this strategy has been the translation of laboratory findings to Phase I and II clinical trials, as exemplified by studies of Epstein Barr virus-induced lymphoproliferative disease (EBV-LPD), a fatal complication in about 15% of recipients of unrelated or mismatched family member bone marrow transplants in the early 1990s. In collaboration with Dr Cliona Rooney, she developed methods for early diagnosis of this disease and procedures for generating cytotoxic T lymphocytes (CTLs) from bone marrow donors. These studies were the first to demonstrate that antigen-specific cytotoxic T cells could eradicate an established malignancy and because the cells were genetically marked, we obtained definitive evidence of cell expansion, trafficking to tumor sites and decade-long persistence. Subsequent protocols have extended this approach to Hodgkins Disease, NHL and nasopharyngeal cancer. She has an additional focus in reconstituting antiviral immunity post transplant in collaboration with Drs. Rooney, Leen and Bollard and is currently leading an NHLBI-funded multicenter trial of allogeneic multivirus specific T cells. She therefore has extensive experience in developing and conducting transplant studies and cell and gene therapy studies under IND and has also obtained orphan drug designation for my initial study. Other areas of research focus in collaboration include identification of novel tumor antigens and genetic modification of CTLs to overcome tumor evasion strategies. In collaboration with Drs. Brenner, Dotti, Savoldo, Gottschalk and Ahded group they are also evaluating if transduction of CTLs with chimeric antigen receptors can allow targeting of CD19+ve, CD30+ve and her2neu+ve malignancies.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia Gulf Coast Consortia Immunology Cluster  Appointments Title Department / School Institution Professor Medicine and Pediatrics Baylor College of Medicine

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