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Faculty Profile Last Modified Time: 12:29:31 PM Tue, 2 Jun 2020   Contact Information Antonella Casola Associated Profiles  Professor, Pediatrics, Microbiology & Immunology, UT Medical Branch at Galveston     ancasola@utmb.edu     (409) 747-0581    Web Link    Respiratory Syncytial Viruses, Metapneumovirus, Epithelial Cells, Viruses, Interleukin-8, Virology, Cell Culture, Molecular Virology, Virus-Host Interactions, Virus Diseases    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  MD Medicine 1989  Research and Expertise Research Interests   Dr. Casola is a physician-scientist specialized in pediatric infectious diseases, with research expertise in the area of respiratory viral pathogens, lung inflammation, and cellular signaling. Her research is focused on the investigation of viral- and host-specific mechanisms that contribute to the pathogenesis of respiratory viral infections. Over the past several years, she has identified several inducible intracellular signaling pathways activated by respiratory syncytial virus (RSV) in airway epithelial cells with particular emphasis on the role of reactive oxygen species in RSV induced lung inflammation both in vitro and in vivo, using a mouse model of RSV infection. Recent investigations in her laboratory have uncovered a very important role of the endogenous gaseous mediator hydrogen sulfide in paramyxovirus replication and cellular signaling. Dr. Casola's research efforts include investigating the pathogenesis of respiratory diseases caused by human metapneumovirus (hMPV), using molecular virology and animal model approaches, to investigate hMPV-induced lung disease and test novel antivirals and therapeutic agents.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia Gulf Coast Consortia Immunology Cluster  Appointments Title Department / School Institution Professor Pediatrics, Microbiology & Immunology UT Medical Branch at Galveston

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