Three main ideas underscore the work the Bailey lab: 1) To identify the genetic, epigenetic, whole transcriptome, and paracrine signaling events that regulate epithelial regeneration and transformation. 2) To better understand the genetic and epigenetic processes that regulate cellular plasticity. 3) To identify the genetic and epigenetic events that regulate how different cell types respond to the accumulation of mutations that drive neoplastic progression.

We comprehensively use genetic mouse models, cell culture and human tissue specimens to address a number of targeted hypotheses related to these main goals. We are enthusiastically expanding our translational research efforts and collaborations within the Texas Medical Center Digestive Disease Center, The Ertan Digestive Disease Center and the Department of Surgery.