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Faculty Profile Last Modified Time: 03:11:17 PM Tue, 26 May 2020   Contact Information Gheath Al-Atrash Associated Profiles  Associate Professor, Stem Cell Transplantation and Cellular Therapy, UT MD Anderson Cancer Center     galatras@mdanderson.org    Web Link    Acute Myeloid Leukemia, Fludarabine, Leukemia, Busulfan, Leukocyte Elastase, Stem Cell Transplantation, GATA2 Deficiency, Myeloid Leukemia    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  DO Medicine University of North Texas 2002  PhD Biomedical Sciences, Immunology University of North Texas 2002  BS Biology Abilene Christian University 1995  Research and Expertise Research Interests   About Dr. Alatrash I am a physician-scientist, clinically trained in medical oncology/hematology and scientifically trained in immunology. My ultimate goal is to translate basic science discoveries to the clinical setting, specifically to develop novel immunotherapeutic approaches and discover new antigens that can be effectively targeted in the treatment of cancer. My research focus is to investigate the role of antigen presentation in shaping anti-tumor immunity. I have extensively studied tumor antigens and their processing and presentation, with a focus on immunogenic peptides derived from the azurophil granule proteases neutrophil elastase (NE), proteinase 3 (P3) and cathepsin G (CG). I have made the discovery that CG, NE and P3 are cross-presented by breast cancer, melanoma, leukemia and multiple myeloma, and I am currently studying the potential role of CG, NE, and P3-targeting immunotherapies in these malignancies. I am also studying novel approaches to enhance the homing of T cells to tumor sites, and am co-PI on an NIH initiative, CIMAC, to harmonize correlative studies from large clinical trial working groups. I am particularly well suited to complete my scientific investigations and collaborations, and to make significant contributions to the field of cancer immunology and immunotherapy. As a physician, board certified in medical oncology and hematology, I am heavily involved in the care of patients who are actively being treated with immunotherapy. As a PhD scientist, I am well aware of the importance of generating testable hypotheses and I am highly skilled in designing experiments and interpreting data. I fully understand the need to perform relevant studies in the laboratory that can then be translated to the clinic. Overall, I am well equipped to successfully carry out my research program because of my active clinical experience, my protected research time (75%), the skill of my laboratory research team and my mentorship and collaborations with leaders in the field of cancer immunology and immunotherapy.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia Gulf Coast Consortia Immunology Cluster  Appointments Title Department / School Institution Associate Professor Stem Cell Transplantation and Cellular Therapy UT MD Anderson Cancer Center

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