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Faculty Profile Last Modified Time: 02:47:14 PM Mon, 6 Apr 2020   Contact Information Katharina Schlacher Associated Profiles  Assistant Professor, Cancer Biology, UT MD Anderson Cancer Center     kschlacher@mdanderson.org    Web Link    Lab Webpage    Genome Instability, Fork Protection, DNA Repair, Fanconi Anemia, Breast Cancer, BRCA, DNA Replication, DNA-Directed DNA Polymer, DNA, Mutagenesis, Genomic Instability, Rec A Recombinases, Repair    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Molecular Biology University of Southern California 2006  BS Microbiology Karl-Franzens University 2003  Research and Expertise Research Interests   DNA replication is a master key to cancer growth and therapy. We focus on molecular mechanisms of DNA replication fork stability that suppress familial inherited cancers and provide a unique window on what has gone awry and the underlying disease principles. We discovered and defined replication fork protection, a major genome stability pathway. We developed and apply new methods for single cell and single molecule analyses at replication forks. Our hypotheses and efforts foremost are informed by human biology and by active collaborations with clinicians (hereditary heme, breast cancer, ovarian cancer), and our work is complemented by collaborations with bioinformaticians and structural biologists. Overall, our research aims to provide foundational knowledge to inform advanced therapeutic strategies and develop functional biomarkers to predict disease cause and response.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia Junior Faculty Network  Appointments Title Department / School Institution Assistant Professor Cancer Biology UT MD Anderson Cancer Center

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