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Faculty Profile Last Modified Time: 02:38:40 PM Thu, 26 Mar 2020   Contact Information Mohammad Hossain Associated Profiles  Instructor, Epigenetics and Molecular Carcinogenesis, UT MD Anderson Cancer Center     mbhossain@mdanderson.org     713-834-6251    Web Link    Epigenetics, DNA Repair, Cancer Biology, Glioma, Jute Fibers, Th2 Cells, Corchorus, Adenoviridae, Polymorphism, Nuclear Respiratory Factor 1, Monocytes    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Molecular Immunology Chiba University 2008  MS Biochemistry Dhaka University 2001  BS Biochemistry Dhaka University 1999  Research and Expertise Research Interests   As an Instructor in the department of Neuro-Oncology, MD Anderson Cancer Center, I have focused my research interest to improve current treatment strategies for glioblastoma (GB) patients. Current treatment cares for glioblastoma patients are tumor resection, radiotherapy, chemotherapy, and recently added TTFields but with that the median survival is still not more than 12 months. To understand the role of the aberrant molecular pathways of GBs in the DNA damage response pathway is a crucial step to solve the recurrence/resistance of GBs to therapies. I have largely focused my research area to understand the biology of GB in response to DNA damage and my research identified a novel mechanism that tyrosine kinase receptor, TIE2, upon radiation translocates to the nucleus and phosphorylates core histone H4 at Tyr51 and recruit ABL1 (cAbl) in the DNA damage site along with other DNA repair proteins to show radioresistance. Our data also find the link between Core Histone phosphorylation and ABL1-mediated DNA repair as inhibition or silencing of ABL1 impedes DNA repair efficiency. We reported our data in Science Advances. I am also involved in some novel projects to find out detail mechanism of radioresistance of glioblastoma, I am also interested to find the genome-wide distribution of TIE2, H4pY51 and PIK3R1 by ChIP-Seq, PIK3R1 was found as reader of H4pY51 in our SH2 protein array and PIK3R1 relation with DNA repair through histone phosphorylation will open a very optimistic treatment strategy for cancer patients.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia Junior Faculty Initiative  Appointments Title Department / School Institution Instructor Epigenetics and Molecular Carcinogenesis UT MD Anderson Cancer Center

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