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Faculty Profile Last Modified Time: 10:59:58 AM Wed, 25 Mar 2020   Contact Information Nhat-Tu Le Associated Profiles  Associate Professor, Cardiovascular Sciences, Houston Methodist Research Institute     Nhle@houstonmethodist.org     713-363-8080    Web Link    Sumoylation, Endothelial Cells, Apoptosis, Atherosclerosis, Phosphorylation, Mitogen-Activated Protein Kinase 7, SUMO-1 Protein, Streptococcus Pneumoniae, Ubiquitin, Inflammation    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Microbiology Sungkyungkwan University College of Pharmacy 2008  Research and Expertise Research Interests   Many agents used in cancer treatment result in significant vascular complications such as angina, myocardial infarction, venous or arterial thrombosis, and newly developed or worsened hypertension. These events are caused by the dysfunction of endothelial cells including apoptosis, inflammation, and decreased NO production. Nhat Tu Le's research group has developed various systems to examine disturbed flow-induced signaling both in vitro and in vivo, and found the formation of a pro-inflammatory and pro-Senescence complex consisting of p90RSK, shelterin complex member, and p65. They have also found that endothelial ERK5 plays a role in regulating statin-induced anti-inflammatory effect using the mouse heart transplantation model. Recently, she discovered MAGI1 (the membrane-associated guanylate kinase-1) as an unexplored molecule that regulates both endothelial inflammation and anti-viral response. Our long-term goal is to establish an "Onco-cardiology" research field at the Houston Methodist Research Institute.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia Gulf Coast Cluster for Regenerative Medicine  Appointments Title Department / School Institution Associate Professor Cardiovascular Sciences The Methodist Hospital Research Institute

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