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Faculty Profile Last Modified Time: 10:55:48 AM Wed, 25 Mar 2020   Contact Information Thomas Kent Associated Profiles  Robert A. Welch Chair Professor, Institute of Biosciences and Technology, Institute of Biosciences and Technology -TAMHSC     tkent@tamu.edu     (713)677-7523    Web Link    Lab Webpage    Carbon Nanochemistry, Oxidative Phosphorylation, Mitochondria, Reactive Species, Stroke, Trauma, Neurodegeneration, Neuroprotection    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  MD Medicine University of Kansas Medical Center 1979  BA Economics University of Kansas 1976  Research and Expertise Research Interests   Carbon nanoparticles derived from a special oxidation of a variety of carbon rich sources are remarkably high capacity mimetics of superoxide dismutase, overcoming many limitations of conventional antioxidants while providing additional actions of considerable biological interest. Our prototype material is termed "pegylated hydrophilic carbon clusters", or PEG-HCCs. Since most injuries, especially ischemia/reperfusion, overwhelms endogenous antioxidant protection, these materials have applicability to a wide variety of pathologies. Moreover, their chemical structure attracts them to mitochondria, where we see an ability to shuttle electrons and therefore potentially overcome genetic or acquired disorders of mitochondrial electron transport. Our current work is directed at determining their mechanism of action in order to optimize their range of favorable properties, with the immediate goal to develop a therapy for human diseases of disorders of oxidative phosphorylation. A longer range goal is to determine their effect on progressive decline in brain function due to accumulation of oxidative injury to DNA and mitochondria.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia GCC Cluster NanoX  Appointments Title Department / School Institution Robert A. Welch Chair Professor Institute of Biosciences and Technology Institute of Biosciences and Technology -TAMHSC Adjunct Professor Chemistry Rice Univ. Adjunct Professor Stanley H. Appel Department of Neurology and Methodist Research Institute Houston Methodist Hospital

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