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Faculty Profile Last Modified Time: 09:02:33 AM Wed, 25 Mar 2020   Contact Information Holger Eltzschig Associated Profiles  John P. And Kathrine G. McGovern Distinguished University Chair, Professor, Anesthesiology, UT Health Science Center at Houston   Medical School Building, Room No.: 5.182    Holger.Eltzschig@uth.tmc.edu     713-500-6222    Web Link    Lab Webpage    Endogenous Adaptive Pathways, Hypoxia-Inducible Factors, Anesthesiology, Critical Care, Perioperative Medicine, Acute Lung Injury, Myocardial Ischemia, Acute Kidney Injury, Intestinal Inflammation    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  MD, PhD Medicine Eberhard-Karls-University 1996  Research and Expertise Research Interests   I am a physician scientist trained in anesthesiology and critical care medicine, and a funded investigator to study the role of hypoxia-elicited adaptive responses in the context of acute organ failure. Many surgical patients experience acute organ injury in their perioperative hospital course, which leads to significant morbidity and mortality. At present, therapeutic approaches to prevent or treat acute organ injury – such as acute kidney or lung injury, intestinal inflammation or myocardial ischemia are very limited. My laboratory is particularly interested in studying endogenous adaptive pathways that are under the control of hypoxia-inducible factors. We have applied these molecular concepts in a wide range of disease models that are important for the field of anesthesiology and critical care medicine, including myocardial ischemia, acute kidney injury, liver ischemia or acute lung injury and intestinal inflammation. Many of our studies point towards an adaptive role for hypoxia-elicited signaling pathways, for example by attenuating hypoxia-associated inflammation or promoting ischemia tolerance. We are currently exploring translational approaches to take these findings from bench to bedside, and we anticipate that some of these findings will lead to novel approaches to prevent or treat acute organ injury in patients who require major surgery or suffer from critical illness. My research laboratory is particularly devoted towards providing junior investigators with unique training and career opportunities. As such, I have trained many scientists and physician scientists from the field of anesthesiology, surgery, immunology and critical care medicine. Several of my trainees went on to become funded investigators (e.g. via NIH K08 or R01 mechanisms) or took over academic leadership roles.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia Gulf Coast Consortia Immunology Cluster  Training Grants Training Interdisciplinary Pharmacology Scientists  Appointments Title Department / School Institution John P. And Kathrine G. McGovern Distinguished University Chair, Professor Anesthesiology UT Health Science Center at Houston Chairman Anesthesiology UT Health Science Center Houston Professor Anesthesiology, Surgery, and Biochemistry UT Health Science Center Houston Associate Vice President Translational Medicine UT Health Science Center Houston

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