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Faculty Profile Last Modified Time: 09:35:44 AM Tue, 21 Apr 2020   Contact Information George Eisenhoffer Associated Profiles  Assistant Professor, Genetics, Basic Science Research, UT MD Anderson Cancer Center   1515 Holcombe Blvd, Unit 1010, Room No.: S11.8136C    gteisenhoffer@mdanderson.org     713.563.2754    Web Link    Lab Webpage    Zebrafish, Epithelium, Planarians, Cell Count, Stem Cells, Epithelial Cells, Mycology, Mucormycosis    Associated Profiles Professional Preparation Research and Expertise Appointments  Professional Preparation  Degree Major Institution Year  PhD Cell and Molecular Biology University of Utah 2008  BA Microbiology The University of Texas 1999  Research and Expertise Research Interests   My lab focuses on understanding the coordination of cell division and death to control overall cell numbers in epithelia. Epithelial tissues provide an essential protective barrier for the organs they encase, and are the primary sites where most solid tumors or carcinomas form. Alterations in both cell loss and proliferation have been implicated in numerous human diseases, including cancer, yet our knowledge of how these two processes influence each other to regulate cell numbers within normal epithelia remains limited. The goal of our research is to elucidate the mechanisms that regulate epithelial cell turnover while preserving barrier function. Our work has uncovered that mechanical forces guide the inter-relationship between cell death and division during homeostatic cell turnover in epithelia, and that damage elicits a separate but equally important response. We have found that cell extrusion, a process used to eliminate cells from epithelia without disrupting barrier function, is the key to driving turnover in both scenarios. To investigate extrusion in a living epithelial tissue, we developed a cellular and molecular toolset to study the epidermis of developing zebrafish. This system provides unparalleled access to analyze epithelial cell turnover in vivo and in real time. We utilize a combinatorial approach that involves timelapse imaging and reverse genetic techniques to characterize cell turnover under physiological conditions, after damage, and when extrusion is perturbed to gain a better understanding of the specific alterations that lead to epithelial pathologies and cancer.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Appointments Title Department / School Institution Assistant Professor Genetics, Basic Science Research UT MD Anderson Cancer Center

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