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Faculty Profile Last Modified Time: 01:54:55 PM Mon, 20 Apr 2020   Contact Information Roderick Dashwood Associated Profiles  Professor & Director, John S. Dunn Chair in Disease Prevention, Center for Epigenetics & Disease Prevention, Institute of Biosciences and Technology -TAMHSC     rdashwood@tamu.edu     713-677-7806    Web Link    Lab Webpage    Gene Expression, Cell Signaling, Apoptosis, Cell Proliferation, Cancer Cell Biology, Cancer Biomarkers, Epigenetics, Cancer Cells, Tumor Biology, Biomarkers, Molecular Oncology, Liver, Oxidative Stress Biomarkers, Cancer Cell Signaling    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Genetic Toxicology/Carcinogenesis University of Portsmouth 1986  MS Toxicology University of Surrey 1983  BS Biological Sciences University of Plymouth 1982  Research and Expertise Research Interests   The current focus is on genetic and epigenetic mechanisms in cancer development. The genetic basis of cancer is studied through cultured human cancer cells and whole animal approaches, including transgenic and knockout models. These models are employed to examine changes in oncogenes and tumor suppressors (e.g., K-ras, ²-catenin, APC) and the influence of chemoprotective agents and anticancer drug candidates. The epigenetic basis of cancer is studied through work on histone deacetylase (HDAC) inhibitors and changes in protein acetylation in both cancer cells and normal cells treated with dietary agents/anticancer drug candidates. Sulforaphane from broccoli, garlic organosulfur and organoselenium compounds and a short-chain fatty acid derived from gut fermentation of dietary fiber (butyrate) inhibit HDAC activity in human cancer cells and trigger growth arrest/apoptosis. The molecular mechanisms are pursued. To translate this work to humans, HDACs and protein acetylation changes are being examined in volunteers undergoing screening colonoscopy exams.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia Gulf Coast Cluster for Single Cell Omics  Training Grants The Cancer Therapeutics Training Program (CTTP)  Appointments Title Department / School Institution Professor & Director, John S. Dunn Chair in Disease Prevention Center for Epigenetics & Disease Prevention Institute of Biosciences and Technology -TAMHSC

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