The Fu lab is interested in using the visual system to study protein trafficking, sensory transduction, the biological mechanisms underlying various types of neurodegeneration and to develop innovative treatment strategies. Recently, the Fu lab has made significant progress toward the understanding of two blinding diseases: Leber congenital amaurosis (LCA), the most severe retinal dystrophy in early childhood, and age-related macular degeneration, the leading cause of irreversible blindness in the elderly. The PI has won the National Eye Institute Audacious Goals Challenge Prize (http://www.nei.nih.gov/challenge). A recent exciting project in the lab is to permanently correct disease-associated mutations in a patient using molecules that are specially designed to target mutated DNA sequences (such as CRISPR) and that can be delivered safely and efficiently into the tissue. Such strategies could potentially provide the best cure or prevention for many diseases, which has the potential to forever transform healthcare. The Fu lab is particularly interested in using the visual system to address post-genomic era challenges (e.g. translate enormous genetic information to functional information). We place emphasis in "Translational Research": from "discovering mechanisms" to "developing innovative treatment strategies" to "moving into clinical trials".
Publications/Creative Works
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Affiliations
Research Consortia
Gulf Coast Cluster for Single Cell Omics
Appointments
Title
Department / School
Institution
Associate Professor, Sarah Campbell Blaffer Endowed Chair
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