Retinal Cell Fate Determination, Development, and Function in Drosophila and Vertebrates, Drosophila Melanogaster, Eye Proteins, Drosophila Proteins, Eye
The primary goal of our research is to understand the molecular mechanisms of retinal development with the ultimate goal of improving our ability prevent, diagnose, and treat human retinal disease. To this end, we are using two animals, the mouse Mus musculus and the fruit fly Drosophila melanogaster, as model systems to identify and determine the function of conserved genes required for normal retinal development. In spite of substantial differences between vertebrate and insect retinal morphology, genetic mechanisms of retinal development have been conserved for more than 500 million years. Thus, study of the molecular and genetic pathways controlling Drosophila eye development has provided a valuable set of tools with which to decipher the development and function of the vertebrate retina. In addition, the mouse provides a powerful model system to decipher the function of newly identified human retinal disease genes and to conduct gene therapy studies.
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