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Faculty Profile Last Modified Time: 01:53:36 PM Wed, 19 May 2021   Contact Information Guillermina (Gigi) Lozano Associated Profiles  Professor and Chair, Department of Genetics, UT MD Anderson Cancer Center     6767 Bertner Avenue, Houston, TX 77030        gglozano@mdanderson.org    Web Link    Lab    Genetics, p53, transcription, tumor suppression, signalling pathway, p53 inhibitors - Mdm2 and Mdm4    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Biochemistry Rutgers University 1986  BS Biology Pan American University 1979  Research and Expertise Research Interest   Mutation of the p53 gene is a critical event in the elaboration of many tumors of diverse origin. The p53 protein is activated in response to DNA damage, serving as a checkpoint in the elimination or repair of cells with damaged DNA. Alterations in components of the p53 pathway, such as amplification of the Mdm2 gene, which encodes a p53 inhibitor, also contribute to tumorigenesis. The overall goal of my lab is to understand the signals that regulate the p53 pathway and the consequences of expressing wild-type or mutant p53.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Training Grants NLM Training Program in Biomedical Informatics & Data Science for Predoctoral and Postdoctoral Fellows Training in Precision Environmental Health Sciences (TPEHS)  Appointments Title Department / School Institution Professor and Chair Department of Genetics UT MD Anderson Cancer Center

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