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Faculty Profile Last Modified Time: 10:27:24 AM Fri, 27 Mar 2020   Contact Information Daniel Frigo Associated Profiles  Associate Professor, Cancer Systems Imaging, UT MD Anderson Cancer Center   MDA 3SCR4.3618 (Unit 1907)    frigo@mdanderson.org     713.563.9673    Web Link    Lab Webpage    Prostatic Neoplasms, Androgen Receptors, Androgens, P38 Mitogen-Activated Protein Kinases, Autophagy, AMP-Activated Protein Kinases, Growth, Transcription Factor AP-1, Cancer Biology, Cell Biology, Signal Transduction, Cancer Research, Oncology    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Molecular and Cellular Biology Tulane University 2003  BS Biochemistry University of Notre Dame 1998  Research and Expertise Research Interests   Steroid hormones are chemicals that are made in one part of our body and can travel great distances to signal specific events in other parts of our body. At the molecular level, steroid hormones communicate by binding to and activating a class of proteins known as nuclear receptors. These hormone-bound receptors can then turn on or off cellular signaling pathways that collectively control different biological responses. For example, androgens, such as testosterone, are steroid hormones that are produced mainly in the testes and can circulate through our bloodstream to various targets like the prostate where the hormone promotes the development of this organ by binding to and activating androgen receptors (ARs). Importantly, while androgens are required for males to develop normally, abnormal androgen signaling can promote prostate cancer. Despite the known importance of androgens in prostate cancer, it is still unclear which androgen-regulated signaling pathways cause progression of the disease. To address this, my laboratory takes a multidisciplinary approach that encompasses fields spanning from genomics to pharmacology to biochemistry to molecular and cellular biology and testing in preclinical animal models. This approach facilitates the identification of those pathways that are actually driving the stages of the disease for which patients have limited treatment options. Most recently, we have been focused on understanding how these pathways alter cellular metabolism to promote disease progression. Now, we are also positioned to rapidly test whether these newly identified metabolic pathways represent realistic therapeutic targets and hence, set the foundation for developing mechanistically innovative drugs.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia Gulf Coast Cluster for Translational Imaging  Appointments Title Department / School Institution Associate Professor Cancer Systems Imaging UT MD Anderson Cancer Center

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