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Faculty Profile Last Modified Time: 11:23:02 AM Wed, 25 Mar 2020   Contact Information Niki Zacharias Millward Associated Profiles  Assistant Professor, Cancer Systems Imaging, UT MD Anderson Cancer Center   MDA B7.4846 (Unit 0026)    nmzacharias@mdanderson.org     713.792.5226    Web Link    Imaging Techniques, Magnetic Resonance, Nicotinic Receptors, Silicon, Polarization, Ovarian Neoplasms, Molecular Imaging, Amino Acids    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Chemistry Caltech 2003  BS Chemistry Texas A&M University 1997  Research and Expertise Research Interests   My science focuses on urological cancers and uses an interdisciplinary approach to interrogate malignancy, metastatic progression and treatment. We work at the interface between chemistry, biology, biomedical imaging and clinical science with our major focus in two areas: 1) the determination of the metabolic profile of different phenotypes of urological cancers for biomarker discovery and to study targeted metabolic therapy and 2) the generation of novel imaging compounds to non-invasively diagnosis phenotype such as metastatic versus indolent and monitor efficacy of treatment. We utilize both cell culture, patient derived cancer xenograft (PDX) animal models and clinical biospecimens in our research. The laboratory uses magnetic resonance (MR) approaches to determine the metabolic profile of tissue, urine and plasma samples both ex vivo and in vivo with a technique called hyperpolarized MR. In hyperpolarized MR, a compound with enhanced signal (> 10,000 fold signal enhancement due to hyperpolarization) is injected into the blood stream and its metabolic conversion is monitored in real-time and in vivo. With hyperpolarization, we have been able to observe metabolic flux differences between cancer cells lines and PDX models.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia Gulf Coast Cluster for Translational Imaging  Appointments Title Department / School Institution Assistant Professor Cancer Systems Imaging UT MD Anderson Cancer Center

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