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Faculty Profile Last Modified Time: 11:57:36 AM Mon, 20 Apr 2020   Contact Information George Rodney Associated Profiles  Associate Professor, Molecular Physiology, Baylor College of Medicine     rodney@bcm.edu     (713) 798-5797    Web Link    Lab Webpage    Cell Culture, Cell Signaling, Proteins, Cell Biology, Biochemistry, Electrophysiology, Physiology, Signal Transduction, Protein Biochemistry, Reactive Oxygen Species, Oxidative Stress, Skeletal Muscle Physiology, Muscle Contraction    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Molecular Physiology & Biophysics Baylor College of Medicine 2001  MS Physiology UT Health San Antonio 1996  BS   Eckerd College 1991  Research and Expertise Research Interests   The research in the Rodney Lab revolves around the study of muscle physiology and function, with a focus on Ca2+ channels and redox signaling and how these processes are altered under conditions of stress, injury and pathology. Skeletal muscle contraction is activated through voltage dependent release of Ca2+ from the intracellular storage location, the sarcoplasmic reticulum (SR) through ryanodine receptors (RyR). Ca2+ release through RyR is regulated by endogenous proteins (e.g. calmodulin), Ca2+, and reactive oxygen species (ROS). ROS have long been associated with inflicting biological damage and have been implicated in the pathology of many conditions, including neoplastic, cardiovascular, respiratory, inflammatory and degenerative diseases, as well as aging, muscular dystrophy, and muscle fatigue. Over the last several decades there has been mounting evidence that low-to-moderate levels of ROS play important regulatory roles in cells. Due to their reactivity and intracellular spatial buffering ROS are likely to have relatively short diffusion distances, resulting in local microdomains containing high concentrations of reactive species. This would be analogous to microdomains of Ca2+ signaling such as Ca2+ sparks. Understanding the spatial and temporal production of ROS is thus a key element in signal transduction. We use a variety of techniques to assess sub-cellular ROS production (cytosolic, mitochondrial, and the endoplasmic/sarcoplasmic reticulum), excitation-contraction coupling, Ca2+ signaling, and in-vitro force measurements in skeletal muscle. These include confocal fluorescent imaging, fluorescent detection of ROS production, whole-cell patch clamping, immunofluorescence imaging, in-vivo electroporation of cDNA constructs, and use of cells from transgenic and gene knockout animals.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia Gulf Coast Cluster for Translational Imaging  Appointments Title Department / School Institution Associate Professor Molecular Physiology Baylor College of Medicine

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