My research focuses on understanding the structure and function of bacterial nanomachines in situ by using cryo electron tomography (Cryo-ET). In recent years, we have developed a high-throughput pipeline for Cryo-ET data acquisition and processing. This pipeline allows us to automatically and massively collect data and further processing them. This pipeline has been successfully applied to many biological systems/specimens and has addressed many significant biological questions. Understanding of the mechanisms underlying bacterial pathogenesis in humans is a major focus of microbiological research and the elucidation of the infectious process yields practical applications of new antibiotics and improved vaccines. My researches focus on understanding the structure and function of bacterial nanomachines in situ, including phage infection, bacterial flagellar motor and chemoreceptor proteins and bacterial secretion systems.
Publications/Creative Works
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