Cancer Biology, Drug Resistance Mechanisms, Metabolism, Signal Transduction, Androgens, Prostatic Neoplasms, Metabolomics, Sarcosine, Protein Array Analysis
Development and progression of cancer has long been known to be multifactorial. To begin to understand cancer progression with a systems perspective, we need to characterize and integrate the various molecular components involved across the various biospecimens analyzed, defining the new area of Systems Biology or Omics. The emergence of the "Omics" era has shifted the focus from the assessment of individual genes and proteins to examination of a substantial component of the expressed genome and proteome. Deciphering the molecular networks that distinguish subsets of tumors that progress to advanced disease will delineate the etiology of cancer, as well as lead to the identification of biomarkers that will aid in the identification of patients that should be treated. Although such studies have been carried out using genomics, global transcriptomics and to some extent proteomics platforms, few studies have examined metabolomic alterations.
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