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Faculty Profile Last Modified Time: 11:07:21 AM Mon, 20 Apr 2020   Contact Information Isaac Hilton Associated Profiles  Assistant Professor, Bioengineering, Rice University, Assistant Professor, BioSciences     isaac.hilton@rice.edu     713-348-8247    Web Link    Lab Webpage    Genome and Epigenome Engineering, Synthetic Biology, Epigenetics    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Genetics and Molecular Biology University of North Carolina at Chapel Hill 2013  BS Biological Sciences University of Missouri-Columbia 2004  Research and Expertise Research Interests   Appropriately coordinated gene expression programs are central to all cellular functions. Pioneering biomedical research spanning several decades has clarified many of the mechanisms governing human gene expression. Despite this tremendous progress, a comprehensive understanding of how genes are regulated remains both lacking and critically needed. Recent advances in synthetic biology and genome engineering are enabling new ways to manipulate cellular transcription and epigenetic modifications. The Hilton research group is focused upon transforming these cutting-edge synthetic tools into innovative ways to decipher, and ultimately engineer, gene-regulatory mechanisms. Our work is aimed at understanding the fundamental principles of human gene regulation and repurposing these principles to improve the ability to control cellular behaviors and combat human diseases. The Hilton laboratory employs functional genomics, genome and epigenome engineering, and other synthetic biology technologies to achieve its research goals. Efforts span three interrelated areas: 1. Decoding basic mechanisms governing gene regulation in human health and disease. 2. Engineering gene expression programs to predictably control human cells. 3. Developing new synthetic biology tools to manipulate epigenetic marks and transcriptional networks.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia GCC Cluster for Cellular and Molecular Biophysics Gulf Coast Cluster for Single Cell Omics Gulf Coast Cluster for Immunology  Appointments Title Department / School Institution Assistant Professor Bioengineering Rice University

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