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Faculty Profile Last Modified Time: 11:01:39 AM Mon, 20 Apr 2020   Contact Information Helen Zgurskaya Associated Profiles  Professor, Chemistry and Biochemistry, University of Oklahoma     elenaz@ou.edu     405-325-1678    Web Link    Molecular Biology, Microbiology, Antimicrobials, Microbial Molecular Biology, Antibiotic Resistance, Molecular Microbiology, Antibiotics, Bacteriology, Antimicrobial Resistance    Associated Profiles Professional Preparation Research and Expertise Appointments  Professional Preparation  Degree Major Institution Year  PhD   Russian Academy of Sciences 1992  BS   Dnepropetrovsk State University 1989  Research and Expertise Research Interests   Multidrug resistance presents a serious problem in the treatment of bacterial infections. This type of bacterial resistance arises due to the overexpression of transporters that recognize and efficiently expel from cells a broad range of structurally unrelated antimicrobial compounds including antibiotics, detergents, dyes and organic solvents. We seek to achieve an understanding of the molecular and biochemical mechanisms of this phenomenon. Specifically, our goal is to elucidate in biochemical terms the mechanism of multidrug transporters of Gram-negative bacteria that cause devastating diseases in animals and human. We take two converging approaches. One is based on the purification and reconstitution of proteins into the artificial phospholipid bilayer. In this system, we structurally and functionally characterize the individual components of the transport complex, as well as the overall organization of multidrug transporters by using the hydrodynamic, spectroscopic and enzymological techniques. Our second approach is the in vivo and in vitro biochemical evaluation of the individual components, containing genetically engineered mutations in target residues of interest.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Appointments Title Department / School Institution Professor Chemistry and Biochemistry University of Oklahoma

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