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Faculty Profile Last Modified Time: 10:25:29 AM Mon, 20 Apr 2020   Contact Information Wenbo Li Associated Profiles  Assistant Professor, Biochemistry and Molecular Biology, UT Health Science Center at Houston   MSB 6.178    wenbo.li@uth.tmc.edu     (713)500-6103    Web Link    Genomics, Epigenomics, Bioinformatics, Long Noncoding RNAs, Enhancer RNAs (eRNAs), Enhancers, Three-Dimensional Genome Architecture, Cohesin and Condensin, Genomic Variations/Mutations, RNA Binding Proteins    Associated Profiles Professional Preparation Research and Expertise Appointments  Professional Preparation  Degree Major Institution Year  PhD Molecular Neuroscience National University of Singapore 2009  BS Biotechnology Zhejiang University 2004  Research and Expertise Research Interests   An amazing feature of eukaryotic nuclei is that as long as 2 meters of DNA in linear length (3 billion base pairs in humans) is packaged into a space of less than 10 ¼m a diameter, while the information stored in all regions of this stretch of DNA can still be very quickly (in minutes or seconds) and effectively retrieved. (This process is so effective and precise that it very likely outperforms the Google search engine!). Despite being so small, every human genome hosts millions of regulatory genomic elements, including enhancers, promoters and insulators, that they cross talk to each other every single second to control DNA replication, genome integrity and gene transcription. The ultimate goal of Dr. Li's lab is to understand how the genome is organized in the three-dimension (3D), and how the elements in the genome, including both DNAs and RNAs, cross-talk to each other. Importantly, the mutations of genome regulatory elements, such as enhancers and promoters, are associated with various diseases, but are mostly mysterious in terms of their underlying mechanisms. The basic molecular insights into 3D genome will be doomed to help us fight human disease such as cancers.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Appointments Title Department / School Institution Assistant Professor Biochemistry and Molecular Biology UT Health Science Center at Houston

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