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Faculty Profile Last Modified Time: 01:43:38 PM Mon, 20 Apr 2020   Contact Information Walid Fakhouri Associated Profiles  Assistant Professor, Diagnostic and Biomedical Sciences, UT Health Science Center at Houston   BBS 4212    Walid.D.Fakhouri@uth.tmc.edu     713-486-2519    Web Link    PCR, Cell Culture, DNA, Gene Expression, Cloning, RNA, Molecular Biology, Sequencing, Cell Signaling, Proteins, Genetics, Gene Regulation, Antimicrobials, Epigenetics, Regulation of Gene Expression, Mutation, Stem Cell Biology, Transcription    Associated Profiles Professional Preparation Research and Expertise Appointments  Professional Preparation  Degree Major Institution Year  PhD Phytomedicine and Molecular Biology University of Hohenheim 2002  MSc Phytopathology/Bacteriology University of Jordan 1995  BSc Phytopathology University of Jordan 1992  Research and Expertise Research Interests   Dr. Fakhouri's research interests focus on identifying epigenetic and genetic factors that cause and contribute to increase the risk of craniofacial disorders including cleft lip and palate, craniosynostosis and micrognathia. His lab uses mouse models and organ cultures to delineate the molecular mechanism of a novel genetic interaction between two transcription factors, IRF6 and TWIST1, that plays a critical role in regulating the epithelial-mesenchymal interaction during oral, facial and skull development. Using biochemical and genetic approaches, his lab investigates how mutations in TWIST1 phospho-sites disrupt formation of craniofacial tissues derived from mesenchymal cells. Integration of experimental data and bioinformatics for developing computational models are also utilized in Fakhouri's lab to identify etiologic non-coding DNA variants associated with cancer diseases including head and neck squamous carcinoma. The overall goal of his lab research is to translate their bench findings into the clinic to improve risk assessment and pave the way to personalized medicine.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Appointments Title Department / School Institution Assistant Professor Diagnostic and Biomedical Sciences UT Health Science Center at Houston

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