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Faculty Profile Last Modified Time: 01:52:13 PM Mon, 20 Apr 2020   Contact Information Louise McCullough Associated Profiles  Professor and Chair, Roy M. And Phyllis Gough Huffington Distinguished Chair, Neurology, UT Health Science Center at Houston   MSB 7.044    louise.d.mccullough@uth.tmc.edu     713-500-7079    Web Link    Lab Webpage    Stroke, Sex Characteristics, Middle Cerebral Artery Infarction, Brain Ischemia, Wounds and Injuries, Cerebral Hemorrhage, Brain, Estrogens    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  MD   University of Connecticut 1996  PhD   University of Connecticut 1992  Research and Expertise Research Interests   Clinically, stroke is increasingly recognized as a sexually dimorphic disease. Most international databases demonstrate that women enjoy lower stroke incidence relative to men until advanced age. This native neuroprotection is lost after menopause, often attributed to the loss of estrogen. Emerging data suggest that cell death mechanisms in the brain follow differing mechanistic paths that are dependent on sex chromosome compliment in addition to exposure to sex steroids. We have now established that tissue damage and functional outcome after experimental brain injury are shaped by biologic sex (XX vs. XY). We have found that these sex differences also exist at the cellular level, for example XY-derived (male) hippocampal slice cultures exhibited increased caspase-independent cell death after exposure to oxygen-glucose deprivation compared to those derived from XX (female) neurons. Our laboratory also has been investigating differences in inflammatory signaling. Other areas of active investigation in the laboratory include the examination of age-related inflammation in both the brain and peripheral tissues after stroke, peripheral post-stroke immunosuppression, and studies investigating the detrimental effects of social isolation on the immune response to stroke during chronic recovery. We are currently attempting to modulate peripheral age-related inflammation in an attempt to reduce brain injury using bone marrow replacement, and manipulation of the microbiome. Very new work in our laboratory is examining a new model of multi-infarct dementia in aged animals.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia Gulf Coast Consortia Immunology Cluster  Appointments Title Department / School Institution Professor and Chair Neurology UT Health Science Center at Houston

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