I work on statistical genetics, computational biology, bioinformatics, and sequence data analysis. My research is focused on development of computational and statistical methods for analysis of massive data to understand genetics and biology of complex traits. I have been working on the analysis of large-scale next-generation sequencing data, for which I developed statistical models and software pipelines for detecting sample contamination, variant discovery, machine-learning based variant filtering, and genotyping of structural variations. I also work on genetics of diabetes, obesity, and related traits of Mexican American pedigrees. In the ongoing projects, I am working on models that can incorporate heterogeneous genetic and epigenetic data (DNA sequences, methylation, expression level/RNA sequences, Hi-C data) for comprehensive modeling of high-dimensional phenotypes including metabolomics and microbiome profiles.
Publications/Creative Works
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Affiliations
Training Grants
Training in Precision Environmental Health Sciences (TPEHS)
Appointments
Title
Department / School
Institution
Assistant Professor
Epidemiology, Human Genetics & Environmental Sciences
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