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Faculty Profile Last Modified Time: 11:59:39 AM Fri, 27 Mar 2020   Contact Information Robert Waterland Associated Profiles  Professor, Pediatrics-Nutrition, Molecular and Human Genetics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine   Children's Nutrition Research Center, Room No.: Ste. 5080    waterland@bcm.edu     (713) 798-0304    Web Link    Lab Webpage    Environmental Influences on Mammalian Developmental Epigenetics    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Human Nutrition Cornell University 2000  BS Physics Virginia Tech 1987  Research and Expertise Research Interests   Research in the Waterland laboratory aims to understand how nutrition and other environmental influences during prenatal and early postnatal development affect individual susceptibility to various diseases later in life. We are focused on nutritional influences on developmental epigenetics as a likely mediating mechanism. Epigenetic mechanisms are established during development to stably regulate tissue-specific patterns of gene expression. DNA methylation is of particular interest because mammalian one-carbon metabolism, which supplies the methyl groups for DNA methylation, is intimately dependent on dietary methyl donors and cofactors. We use various mouse models to investigate early nutritional influences on the developmental establishment of DNA methylation and associated phenotypes. We are also conducting human studies to identify persistent epigenetic changes associated with early nutritional exposures. We use genome-wide DNA methylation profiling, bioinformatic analysis, bisulfite pyrosequencing, and various gene expression assays. Additionally, we are also investigating the role of epigenetic dysregulation in obesity. In particular, we are using mouse models to study whether maternal obesity and nutrition before and during pregnancy affect developmental epigenetics in the hypothalamus and, consequently, body weight regulation in her offspring.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Training Grants Training in Precision Environmental Health Sciences (TPEHS)  Research Consortia Gulf Coast Cluster for Single Cell Omics  Appointments Title Department / School Institution Professor Pediatrics-Nutrition Baylor College of Medicine

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